The incidence of myocardial infarction remains high in various countries and especially in older age groups. Among the reasons for the development of myocardial infarction in recent years, there is a weakly chronic inflammation associated with the influence of blood interleukins. However, the information content of serum interleukins in elderly patients with myocardial infarction has not been sufficiently studied . The aim of the study: analysis of changes and allocation of informative blood interleukins in elderly patients with myocardial infarction. Materials and methods: On the basis of the city hospital No. 2 in Simferopol, period of 2017-2019, 118 patients with myocardial infarction aged 60-74 years and 40 individuals 60-74 years without myocardial infarction were analyzed for serum interleukins using the enzyme immunoassay method and the Protein contour kit . In the future, the ratio of the probabilities of the studied interleukins and their confidence intervals was calculated. The assessment was reliably performed using the X2 criterion. Results: The statistical significance of the difference in the content of all studied blood interleukins in elderly patients with myocardial infarction and without this pathology in persons of similar age was established. At the same time, in the blood serum of patients with myocardial infarction, an increase in Pro- inflammatory interleukins and a decrease in anti-inflammatory interleukins were found. The odds ratio shows a high risk of developing myocardial infarction in the elderly with IL-8, IL-1ß, IL-2, IL-4, and IL-10. Conclusion: Il-8, IL-1β, IL-2, IL-4, and IL-10 should be considered the leading diagnostic blood interleukins for detecting myocardial infarction in the elderly.