Relevance. Сurrently, the age-related oral cavity syndrome in older people is considered as a potentially new geriatric syndrome or maxillofacial geriatric syndrome [4]. Molecular signs of aging of the oral mucosa begin to appear early enough. Which is a reliable indicator of physiological aging of the body in general [1]. A decrease in chewing ability with loss of functional dentition, oral cavity articulation impairment, swallowing impairment, development of oral diadochokinesis, lead to the development and progression of other geriatric syndromes, such as malnutrition syndrome, sarcopenia and frailty, and a decrease in the quality of life [2,5]. Purpose. To study the features of the pro-inflammatory component of the cytokine profile in chronic odontogenic infection against the background of polymorbid pathology in elderly patients. Materials and methods. The study included 126 elderly patients (60-74 years old, average age 64.2 ± 2.7 years). All patients were divided into 4 groups. Group 1 – apparently healthy people (n = 31), group 2 – patients with local chronic apical periodontitis (CAP) (n = 30), group 3 – patients with CAP and ischemic heart disease (IHD) (n = 32), group 4 – patients with CAP, IHD and type 2 diabetes. Cytokine profile in the blood serum, oral cavity and gingival fluid of all patients was analyzed. Results. In the case of chronic odontogenic infection, the process of tooth bone tissue resorption is confirmed by X-ray and is one of the characteristic signs of the disease. It is obvious that a significant increase in the concentration of necrosis factor alpha (TNF-α) in all studied biological fluids during chronic odontogenic infection activates osteoclasts and indirectly enhances resorptive processes. As polymorbidity progresses, a significant increase in the concentration of TNF-α develops, which further enhances the resorptive processes in the bone tissue of the tooth root. In the case of local chronic odontogenic infection, significant differences between the level of interleukin -1β (IL-1β) in patients and apparently healthy people are found only in the gingival fluid, which, apparently, is associated with the localization of IL-1β-expressing cells in chronic odontogenic infections. Interleukin-6 (IL-6) concentration in the blood serum significantly increases only with an increase in the degree of polymorbidity. At the same time, in case of chronic odontogenic infection, on local level the pro-inflammatory system exhibits a very high level of activity (judging by the concentration of IL-8) in comparison with healthy people, which contributes to the progression of the pathological process. Conclusion. On the level of the whole body, the pro-inflammatory system is moderately active and the degree of its activity correlates with the degree of polymorbidity. The level of TNF-α in blood serum and IL-8 in oral cavity and gingival fluid in case of chronic odontogenic infection can serve as an integral indicator of immune inflammation. The level of IL-1β in blood serum, oral and gingival fluids can be considered as an additional factor characterizing the pathological process in polymorbid pathology.