The study of immediate and long-term results of extended surgical interventions in proximal gastric cancer is a well-studied issue in modern world clinical science. The aim is to investigate the immediate and long-term results of extended surgical interventions in proximal gastric cancer. Material and methods. The object of the study was data on patients with cancer of the proximal stomach, who underwent standard and extended resections in the period 1985 to 2001 inclusive. To study clinical observations, a comparative analysis of two groups of patients was carried out. The control group consisted of patients from 254 patients (55.9%) who underwent resections without lymphadenectomy (LDE), the second, main group included 72 patients (15.8%) who underwent resections with LDE. Results. After standard surgery, postoperative complications and mortality were noted in 31.4±4.5 and 12.3±3.2% of patients, respectively. In the extended version of this type of operation, the immediate results were worse, and amounted to 41.9 ± 9.0 and 16.1± 6.7% of patients, respectively. In the group of patients who underwent GE, the greatest differences in five-year survival rates were noted after standard (8.9±3.0%) and extended resections (27.2± 7.8%) in patients with involvement in the tumor process of the cardia and esophagus. Conclusions:1. Extended regional LDE in proximal cancer surgery is accompanied by worse immediate and at the same time, encouraging long-term results, in comparison with standard resections. Postoperative mortality after standard and extended operations was – 11.0±1.9 and 19.4±4.7%, respectively, the frequency of postoperative complications was -27.9±2.8 and 43.0±5.8% of patients, respectively. The overall five-year survival rate after extended resections was 31.7± 5.9%, and after standard ones - 21.9± 2.8%. 2. Expanded GE is accompanied by a significant increase in mortality (23.6±6.9%) than expanded surgery (16.1±6.7%). There were no significant differences in the total frequency of postoperative complications - 44.7±8.1 and 41.9±9.0%. 3. Tumor lesions of the precardial segments of the esophagus are the most severe factor of an unfavorable prognosis, and significantly worsen the results of surgical treatment of cancer of the proximal stomach, regardless of the type and nature of resection. The five-year survival rates for the spread of the tumor to the esophagus after standard surgery were 25.0 ± 5.1% and expanded - 30.4± 9.8%, after GE - 8.9±3.0 and 27.2± 7.8%, respectively.