Introduction. This review article is devoted to innovative areas of cardiac surgery and contains up-to-date information on the development of minimally invasive methods, which are increasingly competing with classical surgical interventions and are a promising replacement for median sternotomy. Aim: analysis of modern methods of regenerative medicine and minimally invasive methods of cardiac surgery in Russia and other countries. Materials and methods. The source of information on high-tech surgical interventions and regenerative medicine methods was the national medical electronic library of the US National Center for Biotechnology Information "PubMed" and the scientific electronic library "elibrary.ru", the portal of the US Food and Drug Administration (FDA), and as well as other publicly available resources on the Internet. Results and discussion. As methods of regenerative medicine for cardiac surgery, advances in the field of bioprosthetic heart valves for the purpose of their restoration or replacement are described; 3D and 4D modeling and printing of tissues and full-size models of the heart for clarity when drawing up a surgical plan and the prospects for their use as potential transplants. The following are considered as minimally invasive technologies in cardiac surgery: the use of modern compact catheters and robotic surgical complexes for operations to restore or replace heart valves, revascularization of the myocardium and coronary arteries and other manipulations on the heart; implantable mechanical devices; intravascular shock wave lithotripsy to eliminate calcified coronary vessels and stimulate the growth of new vessels; and the use of modern instruments in radiofrequency catheter ablation (RFA)). Conclusions. The development of modern methods of regenerative medicine and surgical interventions in cardiology is aimed at increasing the service life of the transplanted tissue or device and reducing the invasiveness of the procedure. The number of medical and scientific centers that introduce new technologies in the field of cardiac surgery into clinical practice is growing every year. The use of robotics makes it possible to provide minimally invasive access to the inside of the chest and perform a wide range of surgical interventions with higher accuracy than with standard surgery. Planning operations and studying the morphology of heart structures before surgery using 3D printing of a model of the heart and great vessels is becoming increasingly important. Developments in the field of bioprosthetic heart valves are aimed at creating materials that have high biocompatibility and tissue function similar to native tissues of the human body, including the ability to grow and self-heal. Many of the listed technologies are beginning to develop in Russia; currently, most of them are at the stage of preclinical research.