Introduction: The COVID-19 pandemic has marked the arrival of many economic, psychological, social, medical and other impacts around the world. One of them is the accelerated aging of the population. Scientific evidence from literature suggests that glucose levels increase with age, and hyperglycemia contributes to the development of accelerated aging. The purpose of the study: to determine the concentration of glucose and fructosamine in the blood in middle, elderly and senile people during the pre-COVID, COVID and post-COVID periods. Materials and methods: The study was carried out on the basis of a database of results of laboratory blood tests of patients of the Ariadne laboratory information system of St. Petersburg Hospital No. 2: 13923 and 396 results of analysis of glucose and fructosamine concentrations were studied, respectively, in the blood of patients who were treated in the hospital, who applied to the clinic or undergo medical examination on the basis of Hospital. Results: Statistical analysis of the obtained data showed that blood glucose levels increased both in the COVID period and in the post-COVID period in persons of all ages. According to the literature and the results of our study, it is assumed that there is an association between infection with a new coronavirus infection and a change in glucose concentration, with the development of a glycemic profile characteristic of older people Discussion: Data from the scientific literature on the impact of COVID-19 on the human body are characterized by a certain inconsistency. Ambiguous conclusions can be associated with a number of factors. Further research is needed to clarify the impact of COVID-19 on fructosamine levels. Conclusion: Blood glucose increased both in the COVID period and in the post- COVID period in persons of all ages. The data of the scientific literature on the study of the impact of COVID-19 on the human body are characterized by a certain inconsistency. Ambiguous conclusions can be associated with a number of factors. Further research is needed to clarify the impact of COVID-19 on fructosamine levels.