Introduction. According to the World Health Organization, there is an increase in the number of elderly and senile people from the general population. So by 2050, half of the population growth will be due to residents older than 60 years. This is a serious problem for the healthcare system worldwide, because many chronic diseases are associated with age: arterial hypertension, diabetes mellitus, arthritis, coronary heart disease, chronic kidney disease, etc. As a result, older people, as a rule, take from 2 to 9 medications per day, which leads to the appearance of a large number of side effects, a decrease in the quality of life and compliance with the therapy. This phenomenon is called polypharmacy. Reducing the number of drugs leads to the opposite effect. Purpose of the study. To evaluate the effect of renal artery stenting as a method of treatment of vasorenal hypertension on the dynamics of polypharmacy in elderly and senile patients. Materials and methods. The study involved 72 patients aged 60 years and older with a diagnosis of vasorenal arterial hypertension, with hemodynamically significant renal artery stenosis. The median age of the studied patients was 68 [63; 76] years. All patients received drug therapy, including antihypertensive. Most often it was 5 drugs. After performing stenting of the renal arteries, the effectiveness of the operation was evaluated in the form of lowering blood pressure and the dynamics of polypharmacy in the form of a change in the number of drugs taken. Blood pressure decreased in 59 cases - 81.9% (95% CI 71.5 - 89.1%), and a decrease in the number of drugs taken also in 59 patients - 81.9% (95% CI 76.9 - 86, 1%). Conclusion. Renal artery stenting in elderly and senile patients with vasorenal arterial hypertension affects the dynamics of polypharmacy, which manifests itself in the form of a decrease in the number of drugs taken.