Relevance. Identification of the relationship between genetic predisposition and risk factors in the occurrence of malignant neoplasms (ZNO) is an integral part of the medical examination of the population in accordance with article 46 of the Federal law of November 21, 2011 N 323-FZ " on the basics of public health protection in the Russian Federation "(2011, N 48, article 6724; 2013, N 48, article 6165) approved the procedure for conducting medical examinations of certain groups of the adult population, which clearly defines that BMI, genetic predisposition to the occurrence of ZNO based on family history, Smoking and alcohol abuse are an integral part of the survey, and should be recorded during the survey of citizens of the country and serve as a starting point for convincing the patient to abandon them. The aim of the study was to conduct a survey of patients to identify the relationship between genetic predisposition, risk factors and symptoms of malignant neoplasms for early detection of ZNO, as well as to assess the coverage of dispensary follow-up and the presence of risk factors for ZNO. Materials and methods. For this purpose, an original questionnaire was developed, based on the Methodological recommendations "ALGORITHMS FOR detecting CANCER IN the POPULATION of the RUSSIAN FEDERATION", published by the Ministry of health of the Russian Federation in 2009. The questionnaire consists of three blocks: socio-demographic, General health questions, and specialized questions on organs and systems. The main purpose of the survey was to get an idea of the General state of health of the respondents, to identify ZNO in the early stages using a specialized questionnaire, and to analyze the medical examination over the past 3 years. The survey involved respondents who came to outpatient treatment in the period from March 2018 to August 2018 in the outpatient network of the city of Voronezh. There were 993 respondents, including 519 men and 474 women aged 18 to 85 years. The respondents were divided into 7 age groups. The information obtained during the survey included: social status, body mass index, marital status, characteristics of puberty and sexual life, reproductive period of life (in women), past chronic and infectious diseases, concomitant diseases, etc. The questionnaire data was analyzed for socio-demographic indicators, BMI, risk factors, and genetic predisposition to the development of ZNO. Then a comparative assessment was carried out between the group with a genetic predisposition to ZNO and reliable risk factors and the group without risk factors and predisposition, which made it possible to objectively identify both individual leading factors and General parameters for the studied groups. Results: the age group of working-age men was 78% of all male respondents, 71% of women were represented by respondents aged 18 to 59 years. A BMI of more than 25 is considered elevated, defined by dietitians as pre-obesity, this indicator was in 44.9% of men and 36.9% of women. 9.4% of men and 7.4% of women were obese in the first degree. 1.5% of men and 7% of women were obese. Knowing the BMI indicators, we analyzed women with a BMI of more than 25 and a genetic predisposition to ZNO. As can be seen from the presented data, out of 474 female respondents, more than 50% have an increased body mass index. There is a significant difference in the groups of respondents with an increased body mass index and normal weight when answering questions about the presence of a history of chronic inflammatory diseases of the female genital organs, which may increase the risk of developing ZNO Conclusions: female respondents with an increased BMI had more positive responses about the presence of reproductive organs and mammary glands in close relatives THAN in groups with a normal BMI. In the same group, 29.6% had a history of mastopathy, compared to the normal weight group, where only 8% had mastopathy. Flattening or retraction of the nipple, the appearance of nodes in the mammary glands, seals, as well as dark or bloody discharge from the nipple were mostly in the group of obese women. based on these data, it was concluded that an increased BMI, Smoking, alcohol consumption and the presence of a history of relatives with ZNO increases the risk of malignant diseases.