Relevance. Herpesviruses are the most common infectious agents found in the human body. In total, 8 types of herpes viruses are known. The sexual route of infection is well documented for the first two types: HSV-1 and 2. The advent of molecular genetic studies has made it possible to widely use the detection of the entire spectrum of herpes viruses, including in urogenital and anal samples. The frequent detection of Epstein-Barr virus, cytomegalovirus and human herpesvirus type 6 in semen and vaginal secretions raised the question of their sexual transmission. Aim. Assess factors associated with sexual transmission of EBV, CMV, HHV-6 Materials and methods. Search in the Pubmed database for the keywords "Epstein Barr virus", "cytomegalovirus", "human herpes virus 6" and "sexual transmission", "sperm", "proctitis". Results. Epidemiological studies with the study of sexual behavior have shown that the prevalence of herpesvirus types IV-VI is affected by the number of sexual partners and the practice of using barrier methods of prevention. Thus, about 2/3 of cases of infectious mononucleosis are associated with sexual intercourse. There is evidence that the detection of STIs is also associated with more frequent detection of viruses. Thus, the presence of N. gonorrhoeae, C. trachomatis and T. vaginalis increases the probability of detecting CMV in urogenital samples by 6.5 times. Conclusion. EBV, CMV and HHV-6 have a number of properties that allow them to be considered as sexually transmitted infections.