Aim: to determine the risk factors for frailty in elderly patients with osteoporotic fracture of the distal radius (DR). Materials and methods: the study included 116 women (average age 66.3 ± 7.7 years) with a DR fracture. Two groups were formed of them: "frailty" and "non-frailty", depending on the presence or absence of frailty syndrome in accordance with the questionnaire "Age is not a hindrance". All participants of the study were assessed for anthropometric parameters, the presence of chronic diseases, nutrition (MNA scale), depression (GDS-15 scale), quality of life related to oral health (dental questionnaire OHIP-14), bone mineral density (T-criterion), vitamin D levels in blood serum to identify factors risk of frailty syndrome. Results: patients with frailty syndrome and DR fracture are older (p = 0.010), malnutrition (p = 0.043) and low BMD of the femoral neck (p = 0.037) had a significant association with the development of frailty in patients with a DR fracture. Conclusions: the obtained results indicate the need for an interdisciplinary approach, including therapy of osteoporosis, sarcopenia, hypertension, diabetes mellitus, coronary heart disease, improvement of the oral cavity, psychological support in order to prevent the frailty syndrome in patients with osteoporotic fractures of the distal radius.