Introduction. In the world population, due to the increase in life expectancy of people, there is an increase in the number of patients suffering from type 2 diabetes mellitus (DM2). Both aging and T2DM are recognized as important risk factors for the development of frailty syndrome. Both of these conditions are often associated with overweight / obesity. Aim. To study the frequency and severity of obesity in frailty syndrome in elderly and senile women with T2DM. Materials and methods. The cross-sectional study included 150 women aged 65 to 85 years (mean age 72.20 ± 1.32 years) with T2DM. Based on the results of the “Age Is Not a Hindrance” Questionnaire, the patients were divided into 3 groups: “robust”, “pre-frail” and “frail”. The paper considers various anthropometric, metabolic and laboratory variables depending on the presence / absence of frailty in patients in the study group. Results. In the group of old and elderly women with DM2, the prevalence of frailty and pre-frailty was 53.45% and 34.6%, respectively. 90.57% of all women were overweight, while 62.27% of individuals were obese. There was no statistically significant dependence of the incidence of obesity among persons suffering from T2DM on the presence / absence of frailty. Among the anthropometric variables studied, waist circumference was the only variable that increased statistically significantly by an average of 6.71 cm in the frail group relative to the robust group (p = 0.045). According to bioimpedance analysis, there were no statistically significant differences in changes in body composition parameters in elderly and old patients with T2DM in the group of patients suffering from frailty relative to the group of patients without this pathology. The average value of the phase angle (5.22-5.43 degrees) in all the studied groups did not depend on the presence / absence of frailty. In the presence of frailty / pre-frailty among elderly and old women suffering from T2DM, the number of blood erythrocytes, hemoglobin, hematocrit, total protein significantly decrease; glycated hemoglobin and blood creatinine significantly increase. Conclusions. All elderly and old women with T2DM showed signs of obesity. The interrelation of indicators of a number of laboratory parameters of blood from the presence / absence of frailty in the study group was established.