Introduction. The COVID-19 pandemic has become a serious problem and challenge for the health system and a global health threat. The analysis of risk factors associated with an unfavorable outcome (lethal) contributes to the accumulation of knowledge to solve this problem. However, data on the association of risk factors for an adverse outcome are often very different or contradictory, even with respect to key predictors. Purpose: to analyze the risk factors for an unfavorable outcome in patients with COVID-19 based on the analysis of data from an infectious diseases hospital. Materials and methods: The retrospective study included data from 5,304 patients admitted to an infectious diseases hospital in 2021 with a diagnosis of "COVID-19, virus identified" and "COVID-19, virus not identified" codes U07.1 and U07.2. according to ICD-10. The following indicators were analyzed as predictors of an unfavorable outcome: age, gender, presence of comorbid pathology, computed tomography data, degree of respiratory failure, saturation and values of laboratory parameters. Results: The following was established: the age of patients with an unfavorable outcome was 70 [60-77] years and was statistically significantly higher (prea was statistically significantly higher (pstically significantly lower (pfavorable outcome. Conclusion. Timely consideration of the identified risk factors contributes to improving the prognosis in patients with COVID-19 and the formation of risk groups for severe course.