Relevance. Diseases of the digestive system due to their high prevalence among the population, the presence of many factors affecting the occurrence of diseases, not enough of their full detectability represent a significant medical and social problem. The incidence of diseases of the digestive system in the Russian Federation tends to increase. Digestive diseases consistently occupy 4-5 places in the structure of total mortality. The purpose of the study: to study the dynamics and structure of the primary and general morbidity of the adult population with diseases of the digestive organs in the Republic of Bashkortostan for 2014-2021. Materials and methods. To conduct the study, the forms of federal statistical observation No. 12 "Information on the number of diseases registered in patients living in the service area of a medical organization" were used. Methods of descriptive statistics were used in the processing and analysis of the material. Results. It was found that the dynamics of the overall morbidity of the adult population with diseases of the digestive system has two periods: from 2014 to 2019, there was an increase of 7.9%, from 2019 to 2021, a decrease of 9.0%. From 2014 to 2021, there was a decrease in the incidence of diseases of the gallbladder and biliary tract, gastric ulcer and duodenal ulcer, gastritis and duodenitis, liver diseases. At the same time, the primary and general morbidity of the population with diseases of the pancreas and the group of diseases "other intestinal diseases" has increased. In this regard, the structure of the incidence of diseases of the digestive system has changed over the years. Discussions. The increase in general and primary morbidity from 2014 to 2021 may be associated with insufficient priority in the fight against diseases of the digestive system. The decrease in morbidity from 2019 to 2021 may be due to the new coronavirus infection COVID-19. A higher primary morbidity in the Republic of Bashkortostan than the average in the Russian Federation may be determined by regional nutritional characteristics. The change in the structure of the morbidity of the population with diseases of the digestive organs may be associated with an improvement in the quality of diagnosis Conclusions: from 2014 to 2019, there is an increase in the general and primary morbidity of the population with diseases of the digestive system and from 2019 to 2021, their decline. It is established that the level of primary and general morbidity of the population in the Republic of Bashkortostan is higher than in the Russian Federation. From 2014 to 2021, the structure of the incidence of diseases of the digestive system in the Republic of Bashkortostan has changed.