Abstract. In the Russian Federation, about 10 thousand non-traumatic operations on the lower extremities are performed annually. According to statistics, the most common cause of amputation is vascular disease. First of all, these are diabetes mellitus (DM) and diabetic foot syndrome (DFS), since the chronic course of diabetes mellitus contributes to the development of multiple organ failure with subsequent gangrene of the lower extremities. The so-called DFS is a severe complication that is found in various forms in 30-85% of patients with diabetes, while amputations are performed 15-40 times more often than in the rest of the population and more than half of patients who have undergone high amputation of the lower legs. limbs due to diabetes die within the first two years, which represents a serious medical and social problem, the significance of which is due to the continuing trend towards an increase in the number of patients, high disability and mortality. In addition, the costs of prevention, diagnosis, treatment and long-term rehabilitation of patients with DFS who have undergone amputations, as well as premature mortality of patients of working age, lead to great economic damage for the state. All these factors determine the need to continue the search and development of new organizational and medical technologies for the diagnosis, prevention and treatment of this severe complication. Goal. conduct an analytical review of publications on the identification and prevention of complications in diabetic foot syndrome leading to amputation of the lower extremities and summarize proposals for early detection and prevention of complications, as well as identify directions for organizing measures to save limbs in patients with DFS. Materials and methods of research. A content analysis of scientific publications devoted to the early identification of causes leading to the development of diabetic foot syndrome and amputation, as well as features of the prevention of complications and rehabilitation of patients, was carried out. The work used methods of content analysis of scientific publications using the eLIBRARY.RU, PubMed, Web of Science database using keywords - “diabetes mellitus”, “diabetic foot syndrome”, “amputation”, “rehabilitation”. Scientific publications from 2018 to 2023 were considered. A total of 37 literature sources were analyzed, including reviews and expert opinions, from which 24 sources were selected, based on keywords, reflecting the most pressing problems of complications in diabetic foot syndrome, leading to amputation of the lower extremities, early detection and prevention. Results. The article presents a review of scientific publications that present the results of a statistical analysis of specialized care for patients with DFS, showing a decrease in the frequency of high amputations with an increase in the frequency of surgical interventions for DFS against the background of a virtually unchanged proportion of amputations in the structure of all operations. Despite significant quantitative indicators, the outpatient service appears to be insufficiently effective in reaching the target population. Meanwhile, most patients receive care on an outpatient basis. In addition, in all countries, regardless of the local characteristics of the organization of medical care, a patient with DFS initially goes to an outpatient facility. Therefore, the number of emergency hospitalizations with advanced clinical cases and the number of amputations will depend on how care is organized at the prehospital stage. Solving problems caused by the organization of medical care for patients who have undergone non-traumatic operations of the lower extremities and assessing the measures taken to monitor them after amputations is relevant and turning into a medical and social problem. The solution to this problem is to influence the factors influencing the occurrence of diabetes, leading to severe complications and amputation, building a system for organizing early detection and prevention, and subsequently organizing clinical examination, medical rehabilitation and socialization of patients in society. Conclusion. The problem of lower limb amputations remains high today. The risk of lower extremity amputation, leading to loss of ability to work, disability, decreased life expectancy, as well as increased social costs for the treatment of such patients, dictates the need to continue studying the epidemiology of DFS and carry out measures to develop specialized care for patients with DFS both at the regional and federal level. Development of comprehensive measures for medical rehabilitation and socialization of patients who have suffered non-traumatic amputations of the lower extremities.