Relevance. The introduction in the territory of our country since 2013 of a special assessment of working conditions (SOUT) has significantly improved in international ratings the Russian indicators of occupational injuries and occupational morbidity among specialists of various industries. At the same time, the health sector made an exception, because over the past ten years, the occupational morbidity of medical workers working in harmful and dangerous working conditions has increased 2.7 times. In connection with the above, the development of differentiated approaches in the study of harmful and dangerous factors in the integral assessment of the working conditions of medical workers of various specialties is an urgent task. Purpose. Differentiated approach to the selection of the set of the most unfavorable for the health of medical workers adverse production factors by conducting an integral assessment of harmful and dangerous working conditions. Materials and methods. The study of adverse production factors was carried out on the basis of the results of SOUT in 80 medical workers of rural central district hospitals. The study was based on a point assessment of the significance of harmful factors, which determines the existence of a relationship between the values of indicators of harmful working conditions and hygienic classes that form them. This approach was developed and implemented by V. Ivanov (2016) to solve problems in the system of compulsory social insurance of workers in industries associated with occupational risk from the influence of harmful and dangerous working conditions. The integrated assessment of the working conditions of physicians on the basis of multivariate statistical processing was carried out in three stages. The first is the establishment of a class of working conditions on the basis of SOUT; the second is to establish the sum of the points of adverse factors (indicator of the total harmfulness of working conditions) characteristic of each specific medical specialty; the third is the establishment of an integral assessment of working conditions with differentiated exposure to the entire set of harmful factors characteristic of each specific medical specialty. Results. The calculated values of the indicators of the integral assessment of working conditions corresponded to the values of dangerous, amounting to 5.18 cu for emergency physicians, and 3.47 cu for surgeons. For anesthesiologists, they were unacceptably harmful, amounting to 2.27 cu. For neurologists, they were characterized as harmful – 0.13 cu. Discussions. The proposed method of integral assessment of the harmful working conditions of specialists' doctors, in contrast to the one based on SOUT, makes it possible to objectify the quotation of the interpretation of the totality of the complex differentiated impact of production factors. Conclusions. Calculation of indicators of integral assessment of working conditions of medical workers of various specialties, complementing the results of SOUT, makes it possible to reproduce an objective assessment of the differentiated impact of a combination of harmful and hazardous production factors.