Introduction. The dramatic increase in life expectancy throughout the world over the last century has led to a rapid increase in the number of patients with a variety of chronic diseases. The purpose of drug therapy is to prevent the development or treatment of diseases and increase life expectancy, but their irrational use leads to the development of many unwanted side reactions. The purpose of the study. To study the influence of multimorbidity in elderly patients on the development of polypharmacy, to study methods of combating polypharmacy in geriatric practice. Evaluate pestilence experience on this issue in scientific articles posted on the PabMed portal. Materials and methods. The study was carried out in 2 stages. At the first stage of the study, in order to identify comorbidity and determine the level of polypharmacy among elderly patients, we conducted a study with the participation of a group of elderly patients registered with a family doctor aged 65 to 75 years. In order to study in more detail the prevalence of polypharmacy, the 2nd stage of the study was conducted, which included patients from the first stage and patients who had not previously participated in the study. A total of 149 patients took part in the study, with an average age of 74.93 ± 7.04. Results and its discussion. The study revealed an increase in the number of medications taken with increasing age of patients. Most often, patients take 8 or more medications, less often 5 to 8 medications, which indicates a high level of polypharmacy among patients in the study group. The average number of all medications taken by patients in this sample was 7.44 ± 2.97. Patients aged 60 to 69 years took the least medications, and patients aged 70-79 years took the most medications. Thus, patients aged 70-79 years took on average 2.4 more drugs than patients aged 60-69 years. And patients aged 80-89 years took 1.7 more drugs than patients aged 60-69 years. The average age of patients taking 8 or more drugs is significantly higher by an average of 6.8 years than patients taking up to 5 medications. Conclusions. The results obtained indicate a high level of polypharmacy. One of the methods to combat it is deprescribing. The primary care physician plays a critical role in reviewing and managing drug therapy. It is most advisable to carry out deprescribing by primary care specialists (general practitioners, family doctors), since they have detailed information about past and current diseases, as well as the treatment of their patient.