Introduction. Thanks to mass vaccination, the threat of a new coronavirus infection is no longer an emergency. However, the problem of chronic COVID syndrome remains relevant. Literature data suggest a relationship between the gut microbiota and the consequences of COVID-19, but this relationship is still poorly studied. Therefore, the performed research is relevant and practically significant. Research objectives were to study the gut microbiota conditions in elderly and senile cases that have recently had the new coronavirus infection COVID-19. Materials and methods. It was examined 113 elderly and senile cases that have had COVID-19 in the recent history. The gut microbiota conditions were evaluated on the basement of the results of a feces bacteriological examination that were compared with reference values. To assess the effect of the age on the gut microbiota, the cases were divided in three age groups (65-70 years old, 71-80 years old, and 81 years old and older) that allowed building cross-tabulations that were based on the patient's belongings to the age group and the low, normal, or increased quantity of the gut bacteria . The cross-tabulation analysis and other statistical data processing were performed by using the STATISTICA 6.0 application software package. Results and their discussion. More than one half of the cases showed low quantity of Bifidobacterium, Lactobacilli, and E. coli that has normal enzymatic activity. More than one half of the cases had an increased quantity of Klebsiella, Enterobacteria, Pseudomonas aeruginosa, Proteus and lactose-negative E. coli in the gut. The subjects' age increase was accompanied by significant growing of the quantity of Clostridium and non-fermenting gram-negative gut bacteria, as well as a moderate decrease of the quantity of the gut lactose-negative E. coli, Proteus and Klebsiella. The age of the patients also affected the quantity of the gut Lactobacilli, but this effect seemed to be nonlinear one. Conclusion. The results of the study allow concluding that the recent history of new coronavirus infection in the elderly and senile cases affects their gut microbiota. Also, it should be noted the relationship of some elements of the microbiota from the subjects age. All this allows considering that the gut microbiota involved in the development of chronic COVID syndrome and it can be possible application point for geroprotection and therapy of this syndrome.