A comparative analysis of the state of health, socio-economic factors and the presence of emotional burnout syndrome (CMEA) in district nurses and district pediatricians was carried out. 120 medical workers working in children's polyclinics in Orenburg were surveyed, including 64 nurses (53%) and 56 doctors (47%). The methodological basis of the CMEA study was the main provisions formulated in the works of K. Maslach, V.V. Boyko. The state of health was determined taking into account the data of periodic medical examinations and behavioral questionnaires. A statistically significant difference was recorded between the main health indicators of nurses and doctors with a predominance of both somatic and combined pathology in district nurses. The CMEA of district pediatricians is higher than that of nurses, which is associated with greater responsibility for the health of patients, the need to make responsible decisions and provide the necessary medical care. The purpose is to determine the state of health, age composition, and nature of socio-economic factors in pediatric outpatient medical workers. To diagnose the level and severity of CMEA in doctors and nurses. To conduct a comparative analysis of the health status and CMEA of medical personnel. Materials and methods. 120 medical workers, district nurses and district pediatricians, were surveyed using questionnaires developed at the Department of Nursing of Orenburg Medical University. The age of the respondents is from 20 to 50 years and older, 64 of them are nurses (53%), 56 doctors (47%), the place of work is children's polyclinics in Orenburg. The questionnaire reflected age, health status, socio-economic status, relationships in the family and at work. The state of health was determined taking into account the data of the questionnaire and periodic medical examinations. The methodological basis of the CMEA study was the main provisions formulated in the works of V.V.Boyko, K. Maslach. Statistical data processing was performed using computer programs Statistica 10.0 (StatSoft, USA) and Microsoft Office Excel 2017. The nomenclature of terminology in the article was used in accordance with the order of the Ministry of Health of the Russian Federation dated May 2, 2023, No. 205n "On approval of the nomenclature of positions of medical workers and pharmaceutical workers". When processing the studied indicators, 64 respondents were accepted for 100% among the average medical staff, 56 respondents were accepted for 100% among doctors. Results. Among district nurses, there are rather low indicators of somatic health, pronounced deviations in socio-economic factors towards their negative impact on health, as well as moderately pronounced CMEA. Among district pediatricians, compared with nurses, indicators of somatic health and socio-economic factors were recorded at a higher level, however, CMEA was more pronounced in doctors than in nurses working in children's clinics. Conclusion. The data obtained on a comparative assessment of the state of health, socio-economic factors and the severity of CMEA indicate the need for targeted prevention work, including: 1 improving competence in the field of health and the organization of family and moral relations, 2 the ability to use the reserve capabilities of the nervous system, 3 the development of healthy behavior skills using communicative competence. Conclusion. The data obtained on a comparative assessment of the state of health, socio-economic factors and the severity of CMEA indicate the need for targeted prevention work, including: 1 improving competence in the field of health and the organization of family and moral relations, 2 the ability to use the reserve capabilities of the nervous system, 3 the development of healthy behavior skills using communicative competence.