Introduction. In today's world, agriculture plays a key role in ensuring food security and meeting the food needs of the population. Pesticides are widely used in the world to protect plants from pests and diseases, increase yields and preserve the quality of agricultural products. However, their intensive use in agriculture can lead to the accumulation of residues of these substances in food products, which poses a potential threat to human health. Objective: to compare the accumulated experience of domestic and foreign literature data on the regulation of pesticide residues in food products of plant origin to assess the level of awareness and the amount of available data on this issue. Materials and Methods. The number of analyzed sources - 92, of which 37 were selected for review, including scientific publications presented on the following Internet resources: eLibrary, PubMed, Cyberleninka, “ConsultantPlus”, published in the period 2019-2023. The selection of sources was carried out in accordance with the PRISMA criteria. Results. This article presents an extensive review of both domestic and foreign literature. By analyzing the international experience in scientific advances in the field of pesticides, it can be stated that domestic experts face limited access to innovative methods of analysis and modern technologies, which makes it difficult to gain an in-depth understanding of the mechanisms of pesticide effects on the human body. Discussion. The problem of pesticide control in food is a global challenge that requires our close attention. It is important to strengthen international cooperation, share experience and research results, and jointly develop and implement new methods of pesticide control in food. Conclusion. Revision and updating of quantitative standards of pesticides taking into account the recommendations of the World Health Organization (WHO) and other international organizations is extremely necessary. Pesticides can enter the human body by various routes: orally, percutaneously and through the respiratory tract. Chronic exposure to pesticides can lead to the development of serious diseases including cancer, reproductive disorders, nervous system damage, etc.