Introduction. Motor Cognitive Risk syndrome (MCR) is a new syndrome that includes subjective cognitive complaints and decreased walking speed. Early studies have shown that subjective cognitive complaints and slow gait are associated with frailty syndrome (FS) in older adults without cognitive impairment, but there is little data on the relationship between MCR and FS in older and senile adults. Aim: to study the relationship between MCR and its components with FS in older and senile adults. Materials and methods. The study involved 429 people (mean age 76.7±7.7 years). All participants were assessed for complaints, anamnesis, anthropometric parameters, subjective cognitive complaints, walking speed, handgrip strength, GDS-15, MMSE, and FS. According to the MCR criteria, all participants were divided into 4 groups: 1) a group without subjective cognitive complaints and walking speed within the normal range; 2) a group with subjective cognitive complaints only; 3) a group with only reduced walking speed; and 4) an MCR group. Results. The incidence of subjective cognitive complaints, reduced walking speed and MCR was 15.9%; 10.0% and 4.0%, respectively. In the fully adjusted model 3, the results remained unchanged and reduced walking speed (Odds Ratio (OR) 3.40; 95% Confidence Interval (CI) 1.40–8.23) and MCR (OR 5.53; 95% CI 1.46–20.89) were associated with an increased risk of FS. However, no significant association was found between subjective cognitive complaints and FS. Conclusions. MCR and low walking speed are interrelated with FS in the elderly and old people. Further research is needed to determine the causal relationship between MCR and FS in the elderly and senile population, and to develop new treatment, diagnostic and rehabilitation strategies to improve the quality and duration of their lives.