Introduction. The study of activity indicators of regulatory systems is a key method used to assess the integrative capabilities of the nervous system, as well as the adaptive capabilities of the body. To assess the adaptive reserves of the body, the method of analyzing heart rate variability is used, which allows analyzing the voltage of the body's regulatory systems. Timely detection of adaptation disorders will help maintain the health of the population. Objective: to analyze the distribution of indicators of the activity of regulatory systems in students, taking into account risk factors and forecasting results. Materials and methods. The study involved 200 students of the University of humanities, who were divided into groups based on gender and age. A control group was also formed, identical in gender and age, whose respondents did not participate in the educational process. All participants were asked to complete questionnaires and interviews on risk factors, as well as variational heart rate monitoring. The results were processed using parametric and nonparametric statistical methods, and a discriminant function model was developed. Results and discussion. The majority of participants in both groups are in a prenosological state, which is characterized by satisfactory adaptation and the absence of significant deviations in the regulation of activity. Next in prevalence is the norm, characterized by an optimal level of functioning of regulatory systems. The premorbid condition associated with increased vulnerability to the development of diseases is less common. Failure of adaptation, characterized by pronounced disturbances in the regulation of activity, is the least common indicator. The results of the study emphasize the importance of assessing the activity of regulatory systems to identify individuals with an increased risk of adaptation disruption among the entire population, including students. Activity indicators of regulatory systems are important biomarkers that allow determining the level of adaptation and the need for intervention. Conclusion. The study and evaluation of the activity indicators of regulatory systems is an important tool used in the prevention of diseases among the population and allows early detection of health problems.