Introduction. Frailty syndrome (FS, frailty) is a common geriatric syndrome characterized by decreased physiological reserve of the body and dysfunction of organs and systems, which leads to adverse events such as hospitalization, decreased quality of life, disability, dependence on outside help, and death. This syndrome is divided into physical asthenia and cognitive (a combination of physical asthenia and cognitive impairment). Currently, there are limited data on the incidence of FFS, adverse effects, and their relationships in elderly outpatients. Objective: to study the incidence of FFS, adverse effects (hospitalizations over the past year, decreased quality of life), and their relationships in elderly outpatients. Materials and methods: The study involved 198 elderly respondents (mean age 68±5.4 years). Each participant in the study was asked about their complaints, medical history, and was diagnosed using the questionnaires “Age is not a hindrance”, Quality of Life Brief-Old” (WHOQOL-Old), MoCA test, and the GDS-15 depression diagnostic scale. Results: The incidence of physical and cognitive asthenia was 28.78% and 20.70%, respectively. When compared with robust patients, frailty was associated with hospitalization (adjusted odds ratio (AOR) 3.01; p = 0.002), but was not significantly associated with quality of life (AOR 1.98; p = 0.09). However, physical and cognitive asthenia were associated with satisfactory quality of life compared with robust patients (AOR 4.34; p = 0.04 and AOR = 4.28; p = 0.03, respectively). Conclusions: The high incidence of preasthenia and SSA and the relationship with adverse outcomes (hospitalization, decreased quality of life) in elderly outpatients dictate the need for screening for frailty in outpatient healthcare.