Introduction. Healthcare associated infections (HAIs) have a significant impact on morbidity and related health system costs, leading to ineffective treatment, longer hospitalizations, and deaths. The growth of antimicrobial resistance in medical organizations increases the threat to human health, as resistant pathogens can cause serious infections that cannot be cured with affordable medicines. The purpose of the study is to determine the directions of scientific research on the study of HAIs in the world. Materials and methods. The review and analysis of foreign scientific literature devoted to the study of HAIs in some regions of the world: Europe, the Middle East, China, Africa, America, Australia, using PubMed, Google Scholar, Web of Science, RSCI databases and BMJ Group resources for 2021-2024. The results of the study. HAIs, along with antibiotic resistance, are a global global health problem. The research is mainly aimed at identifying the level of prevalence, the microbiological profile of HAIs, the introduction of an epidemiological surveillance system, and new methods for preventing the spread of these infections. Depending on the region and country, the average prevalence of HAIs varies from 6 to 17%, the most common are infections of the surgical area, lower respiratory tract, catheter-associated bloodstream infections, urinary tract infections; the most common pathogens of infections are Acinetobacter baumannii, Escherichia coli and Klebsiella pneumonia. It is likely that, depending on the economic conditions of the level of development of healthcare in general, the current vectors for the prevention of HAIs are determined.