Introduction. Frailty syndrome (FS) is a leading geriatric syndrome characterized by increased vulnerability to the effects of stress factors on the body, resulting from the aging-related decrease in the reserve and functions of many organs and systems. Aim: to study the incidence and risk factors of FS in patients aged 80 years and older. Materials and methods. The study included 200 patients aged 80 years and older (mean age 83.34 ± 3.93 years). All study participants were given complaints, anamnesis, anthropometric measurements, determination of handgrip strength using a hand dynamometer, blood pressure levels, cognitive functions using the Mini Mental State Examination scale (MMSE), physical functioning – using the Short Physical Performance Battery (SPPB), the presence of depression – using the Geriatric Depression Scale (GDS), FS using the questionnaire "Age is not a hindrance". Results. The incidence of FS in the study population was 83.4%, in men - 80.3%, in women - 84.7%. Independent factors increasing the risk of developing frailty were low physical performance capacity (SPPB) (OR: 4.21; 95% CI: 1.12-15.83), depression (OR: 3.35; 95% CI: 1.29-8.73), chronic joint pain (OR: 4.90; 95% CI: 1.97-12.18) and COPD (OR: 3.01; 95% CI: 1.03-8.78), while arterial hypertension showed an inverse association (OR: 0.33; 95% CI: 0.11-0.94). Conclusions. Due to the high incidence of FS among people aged 80 years and older, early diagnosis of risk factors for frailty with subsequent development of an individual complex of treatment, preventive and rehabilitation measures is necessary.