Introduction. Physiological aging is not pathology, but its negative impact on the health of patients is obvious. In this regard, the concept of proxy diseases of aging is of interest, suggesting that age-related diseases should be considered as intermediaries between the physiological and pathological processes that occur as a result of aging of the human body. The aim of the study: to analyze the literature data on multifocal atherosclerosis as a possible proxy disease of the aging. Materials and methods. To achieve this goal, traditional methods of theoretical research were used: induction, deduction, generalization, analysis and synthesis. Data on the relationship between aging and atherosclerosis were collected and analyzed. The features of multifocal atherosclerosis that was considered as possible aging proxy disease were studied. To obtain information, publicly available publications were used that were indexed by the databases Scopus, Web of Science, The Cochrane Library, Global Health, EMBASE, CyberLeninka, RSCI. Results and their discussion. As a result of the study, it was shown that aging causes geriatric syndromes and reduces the physiological reserves of the patient's body. However, aging is not a disease, as it does not have some of its key features. Attention is drawn to the existence of age-related diseases that can be proxy diseases through which the negative impact of aging on human health is realized. The mechanisms of the influence of aging on the development of atherosclerosis are considered. The definition of the concept of "multifocal atherosclerosis" is given; its clinical and pathogenetic features are described that make it possible to consider multifocal atherosclerosis as proxy disease of aging. Conclusions. 1. The negative impact of aging on the health of patients can be realized through age-related diseases. 2. Aging contributes to the development and progression of atherosclerosis; the prevalence of multifocal atherosclerosis in the elderly and senile age is increasing, which allows it to be considered one of the proxy diseases of aging. 3. Cases of multifocal atherosclerosis have a more severe course and a less favorable prognosis than cases of atherosclerotic lesions of one vascular basin.