Background. Women of reproductive age 18-44 y.o. are a special social category of HIV-infected patients who are vulnerable to tuberculosis. Young people of working age with preserved reproductive ability, pregnancy, childbirth and close contact with children, worse treatment results for two infections and the need for longer follow-up are just some additional factors determining the relevance and significance of the problem of co-infection in this age group of women. Aim: to study the current state of the morbidity of tuberculosis combined with HIV infection of women of reproductive age 18-44 y.o. in Nizhny Novgorod region. Materials and methods. Based on the official accounting forms of the federal statistical reporting No. 263/u-TB, No. 8, a statistical analysis of data for the 10-year period from 2015 to 2024 was carried out. The level and dynamics of tuberculosis morbidity of women of reproductive age with HIV infection in Nizhny Novgorod region were calculated. Results. The average age of HIV-infected women with tuberculosis in Nizhny Novgorod region was 36,2±2,6 years, urban women – 34,1±2,2 years, rural women – 33,4±2,3 years. In the region, during the analyzed period from 2015 to 2024, the incidence of active tuberculosis of HIV-infected women of all age groups decreased by 38,4%. The maximum level of the indicator was recorded in 2018 at 7,3 per 100,000 of the corresponding gender, the minimum level in 2024 was 2,8 per 100,000 of female population. A decrease of the tuberculosis morbidity rate during the analyzed period was also observed in the group of women of reproductive age 18-44 y.o. HIV+ increased by 30,1%. The highest level of the indicator was recorded in 2018 – 15,3 per 100,000, the lowest level in 2024 – 4,6 per 100,000. Despite the decrease of the regional morbidity of active tuberculosis of HIV+ women, HIV-infected women of reproductive age 18-44 y.o. predominate in the structure of the tuberculosis morbidity in cities and outskirts of the region. It should be noticed that from 2015 to 2018, in the age group of 25-34-year-olds, HIV-infected women, the morbidity of tuberculosis remained at the highest levels, and since 2019, the dominant morbidity of tuberculosis has shifted from age-related groups of 25-34 y.o. for the age group of 35-44 y.o. in comparison with other ages of women of reproductive age. A similar situation is observed among both urban and rural residents of the region. Conclusion. It is recommended to include HIV-infected women of reproductive age 18-44 y.o. in the tuberculosis risk group. Diagnostic and treatment, preventive and anti-epidemic events should be strengthened in the direction of timely diagnosis and chemoprophylaxis of tuberculosis, early appointment of antiretroviral therapy, formation of adherence to treatment and a healthy lifestyle, as this is a special group of the population that makes up the labor and reproductive potential of the state.