Introduction. Arterial hypertension affects 28-38% of the population worldwide, and less than half of these patients receive appropriate treatment. The prevalence of dyslipidemia in some regions reaches 40% of the adult population, and dyslipidemia is often found in individuals with hypertension. The combination of hypertension and dyslipidemia acts synergistically on micro- and macrovascular damage, ultimately increasing the risk of cardiovascular and renal pathology, as well as mortality. Risk management can significantly slow the development of adverse health consequences. The aim of this study was to highlight the synergy between hypertension and dyslipidemia and their long-term health consequences, including increased mortality. Materials and Methods. A search of open-access articles published in the last 10-15 years was conducted in PubMed and Google Scholar. Results. An association between hypertension and dyslipidemia was demonstrated, as well as their increased pathological impact on the vascular wall, including increased wall stiffness, vascular intimal thickening, and atherosclerotic plaque development. Ultimately, these changes increase the risk of developing cardiovascular disease. Discussion. The severity of lipid profile changes influences the risk of developing cardiovascular disease, and hypertension parameters are associated with left ventricular changes and heart disease. Conclusions. Pharmacological therapy with dietary modifications (Mediterranean, DASH diet) and physical exercise (aerobic, strength training) can significantly normalize lipid profiles and blood pressure, leading to a reduced risk of developing cardiovascular disease.