Introduction. The high level of mortality from external causes of death (ECD) in a number of Russian regions serves as a marker of social disadvantage and material deprivation of the population, indicating a deficit in self-preservation behavior among citizens and the limited effectiveness of prevention programs. Reducing ECD mortality creates conditions for preserving the labor potential of the population and increasing life expectancy. Purpose of the study. To characterize the evolution of mortality from ECD in the population of the Komi Republic (KR). Materials and methods. A retrospective epidemiological study was conducted using data from federal statistical reporting forms. Actual and directly standardized mortality rates from intentional and unintentional ECD, as well as from injuries with undetermined intent, were calculated for the male and female, urban and rural populations of the KR. Simple APC-analysis was applied to determine the parameters of intra-cohort (within-generation) and period (intergenerational) dynamics of mortality from ECD groups in 2011–2023. Results. The mortality rate of the urban male and female population of the KR from all ECD in 2011–2023 decreased by 19.8% and 19.4%, respectively; that of the rural male and female population – by 22.0% and 32.3%, respectively. This reduction was primarily due to a decline in mortality from intentional (suicides and homicides) and unintentional causes among residents of both urban and rural settlements. APC-analysis results identify middle-aged men (35-54 years) as the "at-risk group" for premature death from unintentional ECD, and men aged 35-44 years for premature death from intentional ECD. Indirect signs of improved self-preservation behavior were identified regarding intentional ECD (suicides and homicides) among young men (20-39 years), and regarding unintentional ECD among middle-aged and older men (40-64 years). The age boundaries of the "at-risk group" for premature death from ECD and the characteristics of the "beneficiary group" experiencing reduced ECD mortality among women could not be precisely defined. Conclusions. ECD remain the leading source of preventable mortality in the KR population. The characteristics of intra-cohort and period dynamics of mortality from intentional and unintentional ECD among men and women indicate the low effectiveness of prevention programs implemented at the regional level, including those aimed at fostering self-preservation behavior among citizens. Practical application of results. Development and adjustment of regional programs for population prevention and demographic development, as well as for improving the organization of healthcare delivery to the population.