Actually, the opinion of researchers about thrombophilia and its contribution to obstetric complications and miscarriage is not fully formed. The majority of researchers recognized the role of some of its forms, called «criterial» thrombophilia. However, a large number of patients with obstetric complications in the history and recurrent pregnancy loss have hemostatic activation in the absence of «criterial» thrombophilia. This can be explained by the presence of «non-criterial» thrombophilia. Non-thrombogenic mechanisms of thrombophilic mutations and polymorphisms disrupt normal implantation and lead to the development of obstetric complications. «Non-criterial» thrombophilia include polymorphisms of the genes of the main parts of hemostasis and «non-criterial» antophospholipid antibodies, the combination of which corresponds to «criterial» mutation. The article presents a clinical case, characterizes the role of thrombophilia in the development of obstetric complications and vascular complications in the postpartum period. The patient had a heterozygous form of «criterial» thrombophilia (mutation V Leyden). The combination of it with «non-criterial» thrombophilia polymorphisms increased the impact of hemostasis