Restoring work capacity and vocational rehabilitation are crucial for stroke survivors, yet most face significant barriers to returning to work [1, 2, 4]. Employment after cerebrovascular accident remains a key issue in rehabilitation, directly impacting financial security, emotional well-being, and overall quality of life [1, 2, 3]. To improve the effectiveness of work reintegration, a comprehensive study of both facilitating and hindering factors is necessary. Objective. To develop recommendations aimed at successful return to work, as well as to analyze barriers and supporting factors influencing the vocational rehabilitation of stroke survivors. Materials and Methods. A retrospective study of patients with post-stroke outcomes was conducted using aggregated results from reports in the Unified Automated Vertically Integrated Information and Analytical System (EAVIAS) from 2016 to 2023. Results. This study, based on a retrospective analysis of data from 61,164 patients who had suffered a stroke (2016–2023), identified key factors influencing successful return to work. Binary logistic regression allowed us to quantitatively assess the role of demographic, socioeconomic, and medical factors in the work reintegration process. The resulting model demonstrated high predictive value (sensitivity 84.7%, specificity 76.2%) and explained 53.9% of the outcome variance (Nagelkerke pseudo-R² = 0.539), confirming its statistical significance (p