Introduction. The relevance of the spread of tuberculosis, HIV infection and their combination in places of detention, which enclose almost all representatives of marginal groups is not objectionable. Convicts with combined HIV/tuberculosis infection, representing the HIV-positive population as a whole, have the same socio-demographic characteristics as prisoners with HIV infection without tuberculosis. The purpose of this descriptive study is to review the epidemic situation of combined HIV/tuberculosis infection in prisons in the subjects of the North-Western Federal district of Russia in the period of increasing development of the HIV epidemic. Materials and methods. The basis of epidemiological analysis was the form of FGSN: № 61 "information on the contingents of patients with HIV infection", №33" Information on tuberculosis patients", №8" Information on patients with active tuberculosis", the form of the Federal Penitentiary Service (FSIN) Tub-4" Report on tuberculosis patients "and FSIN-6" Information on socially significant diseases in persons held in institutions of the penal system " for the period 2007-2017. Evaluation of epidemiological indicators of HIV infection, tuberculosis and their combination in the prison of the northwestern Federal district produced 100,000 of the contingent of the penal correction system in a comparative perspective with the data in the General population, including in the share ratio with calculation of the P value for the coefficient of angular conversion Fischer. Results. In the North-West of Russia, according to 2017, there are 112 places of deprivation of liberty, which is slightly more than 10.0% of the total number of institutions of the UIS of Russia. The largest number of prisoners with active tuberculosis in 2017 was concentrated in the prisons of the Republic of Karelia (285 people), including in combination with HIV infection (136). There were 43 and 7 such persons in the Arkhangelsk region, 27 and 3 in the Novgorod region, 17 and 5 in the Kaliningrad region, respectively. In contrast to HIV infection, the incidence of tuberculosis in correctional institutions is significantly lower (P