Introduction. The article describes the clinical and biological substantiation the programs of keratoprotection, which is one of the most important tasks of modern gerontology and geriatrics. The relevance of this clinical and biological justification is due to the fact that damage and/or loss of corneal endothelial cells leads to the development of keratoprotection with edema, violation of the transparency of the cornea and a decrease in visual acuity, which is quite common among older age groups and leads to a decrease in the quality of life. The purpose of research. To study the clinical and biological substantiation the programs of keratoprotection in persons of older age groups. Material and methods. The operation of ultrasonic phacoemulsification was chosen as a biological model of corneal damage. The study included 240 people aged 40 to 89 years. It was decided to supplement standard therapy with the use of peptide and non-peptide bioregulators in patients of the main group. In order to assess the quality of life of patients, a special original "Questionnaire to determine the biosocial effectiveness of keratoprotection" was developed. Eye dryness was assessed on a 10-point visual analog scale. Results and discussion. Biosocial determinants are quality of life, visual acuity, dry eyes. Biological effects of multimodal bioregulatory of keratoprotection on the basis of modern peptide (peptide complexes AS-2,5,6,7) and non-peptide bioregulators (L-carnitine, alpha lipoic acid and coenzyme Q10) are associated with an increase in the density of corneal endotheliocyte monolayer in old age on average 108 cells/mm2, and in senile at 65 cells/mm2 within one month of comprehensive keratoprotection. Summary. The clinical and biological point of view was that a multimodal approach to keratoprotection leads to an increase in the speed of postoperative recovery of visual function, reduce the degree of dry eye and 92.2% of people, vision improvement, improve the quality of life in elderly and senile age with a level of 35 to 47 points to a level of 100-103 points according to the "Original of the questionnaire to determine biosocial efficiency keratoprotection ".