Actuality: The polymorbidity of geriatric patients determines the need for the simultaneous application of a large number of drugs (of polypragmasia) affecting the different links of the pathological process. Multiple comorbidities and premorbidly status in geriatric population are factors of a cascade of unwanted adverse reactions of drug therapy. One of directions of optimization of pharmacotherapy in geriatric patients is deprescribing. Purpose: to consider cellular chronoblockers as one of the factors reducing the medicinal load on geriatric patients Material and methods: The published scientific materials on this problem are analyzed. The research polymorbidity at 15168 geriatric patients with the use of modern methods of analysis. Results: The polymorbidity is associated with excessive drug treatment. Polypragmasia is widespread among geriatric patients. With age, not only the total number of registered diseases in women, the number of diseases per 1 woman, but also the number of women with 3 or more diseases increased. Conclusions: The use of cell cronoblockers (succinic acid, taurine, beta-alanine, methylsulfonylmethane, alpha lipoic acid, coenzyme Q10, L-carnitine, L-arginine, selenomethionine) and bioregulatorynutraceutical preparations on their basis softens the manifestation of the main and concomitant pathology and increases the efficiency of eprescribing (revision of drug therapy), and, consequently, allows to reduce the drug load on geriatric patients