Acute myocardial infarction remains an urgent modern problem of medicine and gerontology, and it is important to study the risk factors that cause its development. At the same time, it is necessary to assess the prognostic significance of various risk factors for the disease. The aim of the study was to analyze the prevalence and prognostic significance of stressful events and rest characteristics on the development of acute myocardial infarction in middle – aged patients. Materials and methods: the considered risk factors were studied in 157 middle-aged patients with acute myocardial infarction with concomitant arterial hypertension and in 138 healthy individuals of the same age. the prognostic significance of the studied risk factors was determined using a generally accepted formula. The study found that the most prognostically risk factors are stress, among which the most negative impact a divorce in the family (predictability and 12.3), a major scandal at work (predictability – 6,9), serious illness or injury of a close relative (predictability and 5.9). The influence of rest characteristics on the development of acute myocardial infarction in middle-aged people is significantly lower than that of stress factors. Conclusion: the most prognostically significant risk factors are suggested to be used in the preventive work of cardiologists and gerontologists.