In 2020, an estimated 596 million people worldwide had myopia, of which 43 million were blind. Another 510 million people had uncorrected presbyopia. Given the high prevalence and medical and social significance of diseases of the visual organs, the importance of conducting research aimed at finding biological determinants to justify programs of gerontological prevention and rehabilitation of older people with visual organ pathology to improve their quality of life is shown. Purpose: to identify biological markers of negative functional profile in senile sensory deficits. Material and methods. The study included 288 people of senile age (75-89 years, average age 79.1+1.3 years). The study group consisted of elderly people with visual function deficits due to cataracts-131 people (75-89 years old, average age 78.9+1.2 years) (the study was conducted before cataract surgery). The control group consisted of elderly people without cataracts – 157 people (75-89 years, average age 79.3+1.4 years). All patients were examined according to the method of specialized geriatric examination. Results: Due to the development of pathology of the visual organ, a deficit of visual function is formed. This leads to motor activity decrease (hypodynamia), which potentiates the development of dynapenia/sarcopenia, which in turn leads to a violation of the balance function and increases the risk of falling syndrome. On the other hand, visual function deficiency leads to a violation of psychological wellbeing in the form of moderate depression and, due to a decrease in cognitive stimulation, to cognitive disorders. The lack of visual function, coupled with disorders in the cognitive-psychological locus, increases the risk of developing malnutrition, and with the progression of these processes leads to protein-energy insufficiency, which in turn further intensify the processes of developing dynapenia/sarcopenia. The development of pronounced disorders in the motor locus leads to a decrease in the time spent in the open air and, together with the syndrome of malnutrition, leads to a deficiency of vitamin D, which further intensify cognitive and psychological disorders. Conclusion: As a result, a pathophysiological cascade is formed, leading to multidirectional disorders of the human body functioning in senile age as a single biological system.