Actuality: The resilience is a relatively new concept that characterizes the body's reserve forces and the body's resistance to stress. The decline in the resilience of older people due to their high polymorbidity is a widespread problem in health care. Arterial hypertension is the most common pathology among the elderly population, which can lead to the development of serious disorders and complications. A decrease in the body's reserve forces, namely, a decrease in resilience, worsens the prognosis of the course of this disease, which led to the relevance of the study. Aim: To study the somatic domain of resilience in elderly patients with arterial hypertension. Materials and methods: We selected elderly patients (60-74 years, average age 68.2+1.2 years) with a reduced resilience and divided them into 2 groups depending on the presence of arterial hypertension. The first group included elderly patients without arterial hypertension, which was 66 people (60-74 years, average age 68.5+1.2 years), the second group included elderly patients with artearyl hypertension, which was 96 people (60-74 years, average age 68.1+1.2 years). The indicator of resilience was determined by the Connor Davidson Resilience scale. The immunological and biochemical tests were performed on a ChemWell 2910 Combi biochemical and immunological analyzer. Results: There was a significant decrease in the level of vitamin B12 in patients with arterial hypertension below the reference values, the decrease was 1.8 times compared to elderly patients without arterial hypertension. There was also a significant decrease in the level of vitamin D in patients with arterial hypertension below the reference values by 1.9 times compared to elderly patients without arterial hypertension. With regard to iron levels, it was found that the decrease in elderly patients with arterial hypertension was significant compared to elderly patients without arterial hypertension, which reached the lower limit of the norm. Chronic immune inflammation was detected in elderly patients with arterial hypertension. Significantly increased the level of glucose, LDL, there was a lack of serotonin in elderly patients with arterial hypertension. In elderly patients with arterial hypertension, the L - arginine/ADMA ratio was low, which indicates a high risk of adverse events, in particular, ischemic cerebrovascular and myocardial attacks, which is significant in terms of reducing the resilience of elderly patients with arterial hypertension. While in elderly patients without arterial hypertension, this indicator was quite high. Conclusions: In patients with arterial hypertension, there was a significant decrease in the parameters of resilience by 1.3 times compared to patients without arterial hypertension, which indicates that arterial hypertension is an independent factor in reducing resilience. The most significant factors in patients with hypertension that led to a decrease in resilience were: a decrease in the level of vitamin B12, vitamin D, iron, an increase in chronic immune inflammation, a decrease in serotonin, and a decrease in the L - arginine/ADMA ratio.