Relevance. Congenital epidermolysis bullosa (EBE) is an orphan disease. Face-to-face consultation for patients is very stressful, since movement in a car, wheelchair, dressing and undressing, and removing bandages are extremely painful. At the same time, there is a personnel problem for people living in administrative districts remote from the republican capital due to the lack of qualified specialists. On the other hand, visiting specialist doctors in conditions of a high prevalence of coronavirus infection does not exclude the possibility of infection. Considering the above problems and risks, the optimal solution is to introduce telemedicine technologies for the timely diagnosis and follow-up of patients with congenital epidermolysis bullosa. The aim of the study was to establish the role of telemedicine technologies in the timely diagnosis and follow-up of patients with congenital epidermolysis bullosa. Materials and methods. The results of consultations of 93 patients with congenital epidermolysis bullosa (VBE) in the remote format "doctor - doctor" and "doctor - patient", as well as dynamic monitoring of 8 patients in the software and hardware complex Sberhealth / DocDoc, consisting of sites at https://docdoc.ru/ and https://sberhealth.ru/ in the "Internet"network and the Sberhealth applications / DocDoc for mobile devices. Results. In the remote format, the type and subtype of VBE were established in 92 (98.92±1.07%) patients, and in 1 patient (1.07±1.07%), an unspecified form of VBE was established. Repeated online consultations were due to the need for a detailed study of the family history, anamnesis of the disease and clarification of concomitant pathology. Patients who received the consultation of specialists with the use of telemedicine technologies (93 people) and with face-to-face visits of specialists (34 people) compiled the register of patients with VBE of the Republic of Dagestan. In most of them (614 disorders in 127 patients), a multiple combination of complications from the organs and systems of the body was found. It should be noted that 8 patients were under dispensary observation in a remote format, which represented the most priority solution to the problem. The responsibilities of the management of medical organizations (MO) include paying for the work of a specialist doctor who consults both patients and doctors themselves, in the format of telemedicine. To ensure the quality of visualization of lesions, the mode of lighting and silence, and to obtain the clarity of photo images, it is also necessary to support the online format. Conclusion. Our study has shown that for dynamic monitoring, the most popular for patients with congenital epidermolysis bullosa is the online format of consultations, for which software with a mobile application is needed, which will ensure the protection of the patient's personal data.