Introduction. There are more and more publications in the scientific literature about the impact of the use of mobile electronic devices on the younger generation. The purpose of research was a hygienic assessment of the mode of use of mobile electronic devices with headphones by students and their impact on the state of their hearing organ. Materials and methods. A questionnaire survey was conducted in 2017-2021 years. A survey was conducted of 1218 students of schools and universities of Moscow and the Moscow region and 1000 students of schools and universities of Izhevsk and Tchaikovsky. The inclusion criteria are students of schools and universities, the presence of a signed informed consent, a questionnaire correctly filled out by the respondent or his legal representative, the experience of using mobile electronic devices – a year or more. The conducted research does not endanger the participants and meets the requirements of biomedical ethics. Statistical processing was carried out using Statistica 13 PL. Results. The total time of using mobile electronic devices with headphones on a school day in educational and leisure activities is on average 10 minutes for elementary school students, about 2 hours for middle school students, 2.5 hours for high school students, 2.6 hours for students. The calculation of the relative risk showed that prolonged use of headphones for more than one hour a day increases the probability of negative psychophysiological manifestations by 2.2 times, the occurrence of hearing disorders by 5.1 times. Discussions. Students are recommended to limit the time of using mobile electronic devices, which has a positive effect on their functional state and health. It is necessary to stop using mobile electronic devices when complaints appear. Conclusion. It is necessary to take breaks in the use of headphones after 20-30 minutes of use lasting at least 10-15 minutes, excluding the use of mobile electronic devices with headphones before going to bed and in places with a high noise level, such as public transport.