Introduction. The syndrome of senile anemia is a consequence of age-related changes in the body. One of the main factors is chronic diseases, among which it is important to highlight endocrinopathies, oncopathology, diseases of the cardiovascular system, including hypertension, dementia and depressive disorders. The aim of the study was to study blood parameters in senile asthenia syndrome using traditional and innovative research methods. Materials and methods. As part of the work performed, 73 people were examined. Groups were formed according to age and gender criteria. Blood samples for clinical trials were taken in the morning. Part of the blood was separated for atomic force microscopy. Samples were prepared from it, consisting of a suspension of erythrocytes, previously washed from plasma. Then they were placed on a defatted glass slide for immunohistochemical analysis and placed in a wet Ntegra-Aura chamber for scanning. The use of the method allows, in addition to reducing the time of the study itself, to obtain high-resolution scans of cells, without disturbing their vital activity, shape and native size. Morphometric analysis was carried out in the "Ntegra-Aura" device. During the statistical processing of the data, they were entered into Excel spreadsheets, mathematical and statistical processing was performed using the Statgraphics plus for Windows program (version 10.0). Results. The amount of hemoglobin is lower in the studied elderly patients than in elderly patients, by 1.19 and 1.08 times, and platelets and leukocytes are higher by 1.18 times and 1.3-1.41 times. Conclusion. We found that the indicators of patients had multidirectional changes depending on age and gender. Thus, the amount of hemoglobin, the erythrocyte sedimentation rate, the number of erythrocytes and the average concentration of Hb in the erythrocyte are lower in men and women of old age in comparison with similar indicators in elderly patients. In turn, the number of platelets, leukocytes, the width of distribution of erythrocytes (standard deviation) and the percentage of erythrocytes are higher in them than in elderly patients. Indicators of the average volume of erythrocytes, the average content of Hb in the erythrocyte and the width of distribution of erythrocytes (coefficient of variation) in the studied groups did not differ significantly. Hemoscanning showed anisocytosis, a decrease in the number of discocytes, an increase in reversibly altered transitional and especially degenerative forms in a group of elderly patients.