Introduction. A number of studies demonstrate the presence of the phenomenon of "inflammaging" in persons of older and senile age. The molecular ensemble in inflammaging is commonly referred to as the secretory phenotype associated with aging (SASP phenotype). This phenotype is characterized by an increase in biological markers such as interleukin 6, transforming growth factor β, interleukin 1α, interleukin 8, matrix metalloproteinases in circulating blood. Predicting the possible onset and peculiarities of the course of sarcopenia (as the most widespread geriatric syndrome) in combination with such age-associated pathology as arterial hypertension is an urgent task of modern gerontology. The goal: to study the phenomena of inflammaging in the development of sarcopenia in old age. Materials and methods: the study included 402 elderly people who were divided into three groups depending on the presence/absence of arterial hypertension and sarcopenia: 116 people entered the group of people with arterial hypertension without sarcopenia; in the group of people with hypertension and sarcopenia - 174 people; in the group of people without arterial hypertension and without sarcopenia (control) - 112 people. Serum levels of tumor necrosis factor alpha, interleukin-1, interleukin-4 and CD4/CD8, C-reactive protein expression ratios were determined to evaluate inflammaging processes. Study results: people with arterial hypertension and sarcopenia significantly had a higher pro-inflammatory response, that is, the degree of inflammaging, compared with people with arterial hypertension without sarcopenia and with people without arterial hypertension and without sarcopenia. It should be noted that it was the increase in the ratio of CD4/CD8 expression levels and the level of C-reactive protein that was observed within the pathophysiological continuum in arterial hypertension at the stage of sarcopenia development, which indicated a progressive increase in inflammaging phenomena within the framework of the studied pathophysiological gerontological continuum. Discussion: The findings from the search for adequate biological markers demonstrate an unambiguous relationship between the level of cytokines in circulating blood and the pathophysiological gerontological continuum. As a result, the phenomenon of inflammaging is closely related to age-associated pathology, as an integral part of the continuum. In addition, the presence of geriatric syndrome has been shown to exacerbate inflammatory processes. Conclusions: Thus, the pathophysiological gerontological continuum in sarcopenia is based on the phenomenon of inflammaging, while people with arterial hypertension and sarcopenia significantly (p