Background. The proportion of persons of older age groups in the population is increasing, therefore centenarians are of particular interest, as an example of physiological healthy aging. Aim: to study the physical and functional parameters of male and female centenarians with multimorbidity and frailty syndrome. Materials and methods: a cross-sectional examination was performed on 62 people (23 men and 39 women) aged 90 to 101 years, mean age 92.3 ± 2.4 years. Results. The centenarians had a moderate dependence on outside help in basic and instrumental daily household activities. Regardless of gender, a sufficiently high physical activity in everyday life was characteristic. According to the results of examination for frailty, 6.4% of centenarians are robust, 12.8% are pre-frail, 80.8% are frail. Despite a decrease in upper and lower extremity muscle strength parameters, as well as a decrease in skeletal muscle function, the risk of falls was low. In centenarians, frailty is associated with a decrease in physical activity, Barthel Index and Lowton Index, as well as an increase in the Charlson Comorbidity Index. Statistically significant correlations were found between age, depression level and a number of parameters of physical and functional activity of centenarians. Conclusions. Centenarians are characterized by a high preservation of physical and functional parameters, even taking into account multimorbidity and signs of frailty. It is necessary to increase the functional activity and independence of geriatric patients to improve the quality of life and achieve active longevity.