Introduction. In developed countries, there is a tendency to increase life expectancy. An important task is to maintain a high quality of life for people in the older age group. Prevention of premature ageing plays an important preventive role in the development of age-associated diseases, including vascular nature. Purpose. Analyze the relationship between biological age and pathogenesis of vascular ophthalmic pathology. Materials and methods. The materials used are the existing normative legal acts, clinical recommendations, data from domestic and foreign scientific literature. Results. A comparative evaluation of clinical features characteristic of various types of accelerated aging syndromes (Hutchinson-Guildford, Werner, Cockayne) was carried out. Association of pathogenesis of age-associated diseases with biological age is shown. As an example of pathology associated with age, one of the current ophthalmological diseases of mainly vascular genesis is given - primary open-angle glaucoma, which occupies a leading position in the occurrence of blindness. Modern concepts of glaucoma development, which have a certain connection with biological age, are described. Discussions. Factors of premature aging significantly affect the course of the underlying disease, including socially significant diseases. The pathogenesis of ophthalmic disease of vascular nature - glaucoma - is closely related to such profiles of biological age as the state of metabolism, the functional state of organs, and the cytokine profile. The aggressive course of glaucoma leads to imminent blindness, accompanied by a decrease in the quality of life. Conclusions. Thus, age-related neurogumoral imbalance exacerbates the course of ophthalmic disease. Theories of aging and disease pathogenesis have similar intersecting links.