Aim: to study the structure, age, gender, regional characteristics of mortality from viral hepatitis. Materials. The data of the C51 form for 2015–2020 were analyzed. The figures, unless otherwise indicated, are calculated as a whole for the period 2015–2020. Results. Viral hepatitis is the third leading cause of death from infectious and parasitic diseases in Russia (7.1% in 2020), behind HIV infection (61.1%) and tuberculosis (22.7%). There is an increase of lethality from viral hepatitis (2020 - 0.23%). This may be due to the shift in the prevalence of viral hepatitis to socially vulnerable segments of the population. In the structure of death from viral hepatitis, viral hepatitis C prevails (2020 - 80.6%), most of the deaths from which can be prevented with timely initiation of antiviral therapy. Chronic hepatitis is characterized by a predominance of men (for hepatitis B 56.8%; 95% CI54.5-59.1; for hepatitis C 61.5%; 95% CI60.5-62.5); for acute hepatitis, gender asymmetry is statistically insignificant. In dynamics, there is a decrease in mortality from viral hepatitis in young people with a shift in peak rates to the age of 40-44 years (for chronic viral hepatitis C and viral hepatitis in general) and 50-59 years (for chronic viral hepatitis B). Peak values of mortality from acute hepatitis occur in the elderly. Until 2020, there was an increase in the number of years of life lost as a result of viral hepatitis, which in 2020 amounted to 41,608 years (75.6% due to viral hepatitis C). The loss of labor potential in 2020 amounted to 21,763 years. There is a higher mortality from chronic viral hepatitis in the urban population compared to the rural population (1187.6 and 700.5, respectively). Mortality from viral hepatitis was higher in St. Petersburg and the eastern regions. Conclusion. Although mortality from viral hepatitis is predominantly due to chronic viral hepatitis C and is potentially preventable, the problem of death from viral hepatitis remains significant, perhaps among a socially vulnerable population without the means for treatment. Mortality from viral hepatitis has gender (mostly men die) and age (mostly people of working age die), as well as geographical (highest in the eastern regions and cities) features.