Background. The contribution of the new coronavirus infection (COVID-19) to the overall mortality is under debate. The aim of this study is to evaluate the structure of mortality among the population serviced in a Moscow outpatient center during COVID-19 pandemic. Methods. A retrospective study of the mortality structure of the population serviced in a Moscow outpatient center during the period from 01 December 2020 to 28 February 2021 was carried out. The data of the Unified Medical Information and Analytical System were used. Results. COVID-19 was the cause of death in 34.4% of the cases. Pneumonia not associated with COVID-19 referred to 1.7% of the died. Cancer accounted for 15.3% of deaths, cardiovascular diseases did for 15.6%, surgical diseases did for 4.9%. Despite the fact that the mortality rate of patients with COVID-19 was 1.6%, the development of this disease increased the risk of death by 11.2 times. During the observation period, 6902 people received at least one component of the Gam-COVID-Vac (Sputnik V) vaccine. None of the vaccinated died during this period. Conclusions. COVID-19 makes a significant contribution to the overall mortality of the population, surpassing all other certain diseases. Vaccination against COVID-19 is not associated with increased mortality in the population.