Visual deficiency due to ophthalmic diseases, including diabetic retinopathy and primary occlutral glaucoma develops against the background of neurodegenerative processes and apoptosis of various cells. However, the processes of apoptosis in the elderly with this ophthalmopathology and the reaction of lacrimal fluid interlequins remain insufficiently studied. The aim of the study was to study lacrimal fluid interleukins in patients with diabetic retinopathy and angle-closure glaucoma as predictors of apoptosis in these diseases. Materials and methods: In 88 elderly patients with diabetic retinopathy and angle-closure glaucoma, the content of interleukins in the lacrimal fluid was studied by flow cytometry on the device "Beckton Dickinson FACS Canto 2 (USA)" and in 62 patients of the same age who do not have the above-mentioned ophthalmological diseases. The biological age was calculated using the formula: 40.5+0.371 x chronological age. Results of the study: A statistically significant increase in tear fluid in elderly patients with diabetic retinopathy and angle-closure glaucoma was found compared with patients of the control group IL-2 to 27.2±1.7 vs. 3.6±0.5 pg / ml, IL-17 to 36.5±4.2 vs. 5.8±0.3 pg/ml, IL-8 to 27.4±1.5 vs. 4.1±0.5 pg/ml, IL-1β to 267.5±3.6 vs. 54.3±3.4 pg/ml. The biological age of patients with ophthalmopathology is statistically significantly older than that of patients without ophthalmopathology. Conclusion: IL-2, IL-17, IL-8, IL-1β and IL-4 should be considered predictors of apoptosis among the studied lacrimal fluid interleukins in diabetic retinopathy and angle-closure glaucoma.