Relevance. The leading place in the implementation of the task of preserving labor resources is occupied by the study of the influence of harmful and unfavorable factors of the production environment and the labor process on the health of workers, the features and trends of the formation of occupational morbidity. In the context of the spread of a new coronavirus infection, occupational medicine faces problems that require solving issues of preserving and strengthening the health of medical workers. Objective To study occupational morbidity in the Samara region in the period 2017-2021, to determine the features of the structure and the main trends in its dynamics in the conditions of the pandemic of the new coronavirus infection COVID-19 in 2020-2021. Methods The analysis of the state of occupational morbidity in the Samara region was carried out according to the data of the Samara Regional Center of Occupational Pathology for the period 2017-2021 on the basis of expert, reporting and statistical methods. Results. Occupational morbidity rates in the Samara region exceed the national average, including among healthcare workers. During the analyzed period, in the Samara region, as in the Russian Federation, there is a distinct tendency to decrease the level of chronic occupational morbidity. Since 2018, the reduction of newly diagnosed cases of diseases of the nervous and musculoskeletal systems from overstrain has been particularly significant. Until 2020, the leading place in the structure of occupational diseases was consistently occupied by pathology associated with the impact of vibroacoustic factors. Since 2020, due to the COVID-19 pandemic, the ratio of acute and chronic occupational morbidity has changed: acute occupational morbidity was 50.9% in 2020 and 44.7% in 2021. In the structure of nosological forms of occupational diseases, diseases associated with the influence of biological factors have come out on top, among which the first place is occupied by diseases caused by a new coronavirus infection in medical workers. In the Samara region in 2020-2021, 146 cases of acute occupational disease caused by the new coronavirus infection COVID-19 were diagnosed to medical workers, of which 72 diagnoses (48.63%) were established posthumously. 70.05% of deaths from complications of a new coronavirus infection were persons over 60 years of age. In 2021, 6 diagnoses of chronic occupational diseases associated with a coronavirus infection were established, which determined persistent disability. Conclusion. Тhe change in the indicators and structure of occupational morbidity in the conditions of the COVID-19 pandemic is an important aspect for its prediction in the post-pandemic period. In conditions of high risk of infection of medical workers with SARS-CoV-2, it is necessary to increase COVID-19 research from the standpoint of occupational medicine, further improvement of the occupational safety system, examination of the connection of COVID-19 with the profession.