Introduction. Diabetic retinopathy remains one of the leading causes of visual impairment and its prevalence is steadily increasing as the incidence of diabetes mellitus increases. However, geriatric syndromes in patients with diabetic retinopathy, with the exception of cognitive and anxiety-depressive disorders, remain virtually unexplored. Purpose of the study: Analysis of the prevalence of geriatric syndromes in patients with diabetic retinopathy before and after treatment. Materials and methods. In clinical conditions, 244 patients suffering from diabetic retinopathy were examined, among whom a comprehensive ophthalmological and geriatric assessment was performed in accordance with the recommendations of the Russian Association of Gerontologists and Geriatricians. The leading clinical geriatric syndromes were studied in 244 patients with diabetic retinopathy and 200 patients without this disease. Taking into account the performed comprehensive geriatric assessment, the geriatric tactics of managing patients with diabetic retinopathy (main group, n=127) was scientifically substantiated and implemented. The control consisted of 117 patients with diabetic retinopathy who underwent standard therapeutic measures. The evaluation of the effectiveness of the treatment was carried out after 1 year. Results. Among patients with diabetic retinopathy, the risk syndrome of falls was significantly more often diagnosed 64.2±3.1 versus 12.5±2.3 cases among patients without diabetic retinopathy per 100 examined, the syndrome of falls 45.0±3.2 cases versus 19.5±2.87 cases per 100 examined, anxiety-depressive syndrome 65.8±3.2 cases versus 41.5±3.5 cases per 100 examined. The use of geriatric management tactics in the main group made it possible to significantly reduce the frequency of deficiency syndromes, the risk of falls to 34.4±4.2 versus 60.0±4.6 cases per 100 treated in the control group, the syndrome of falls to 23.2±3.8 cases versus 36.5±4.5 cases, anxiety-depressive syndrome to 32.8±4.2 cases versus 57.4±4.6 cases, respectively. The average number of geriatric syndromes also decreased from 5.8±0.3 to 3.8±0.4 in the main group, and in the control group – from 6.0±0.4 to 5.1±0.3 cases. Conclusion. The prevalence of geriatric syndromes in patients with diabetic retinopathy against the background of implemented management tactics decreased compared to the use of standard therapeutic measures.