Very many results of the researches devoted to influence of a new infection of COVID-19 on work of specialized health services, on emergence and the course of these or those diseases are so far published. At the same time, the works devoted to the analysis of changes of indicators of incidence in country scales in the period of COVID-19 pandemic and also search of the factors causing these changes hasn't enough Research objective: Studying of indicators of incidence of the population in regions of the Russian Federation during the periods connected and not connected with COVID-19 pandemic. Materials and methods: data on each of 85 territorial subjects of the Russian Federation are studied. For assessment of the obtained data arithmetic-mean sizes, specific indicators, a standard deviation of the weight of values from average sizes, variation coefficient were used. Results: in 2020 with the diagnosis of COVID-19 4.96 million addresses with the diagnosis of COVID-19, and in 2021 - 11.82 million addresses are registered. All addresses with the diagnosis of COVID-19 were primary. Level of primary incidence on average in regions of the country in the first year of a pandemic decreased in comparison with previous year by 3.5%, and in 2021 increased by 8.1%. In a number of territorial subjects of the Russian Federation growth of level of primary incidence in 2021 in comparison with 2019 exceeded 20%. More than 11-fold difference between the minimum and maximum values of incidences COVID-19 in a section of territorial subjects of the Russian Federation and also lack of normality of distribution of values of the studied indicators and a wide confidential interval takes place. At the same time the coefficient of a variation of the considered sign makes 47.7% in 2020 and 33.8% in 2021 that demonstrates strong differences between regions on incidence of COVID-19 which can't be explained with different population density. Conclusions: there are factors affecting incidence of COVID-19 which not connected with features it is infections. To heads of executive authorities when planning volumes of primary health care on a case of infectious pandemics, it is necessary to use information sources based on technologies of constant cartographic account and remote monitoring of diseases.