Coronavirus SARS-CoV-2 has neurotropic properties, so, when infected, existing nervous diseases exacerbate and new ones develop. This leads to a change in the structure of causes of death in the population. The purpose of this study: to determine changes in the structure of mortality of Muscovites from nervous diseases against the backdrop of the COVID-19 pandemic. Materials and methods. The change in mortality of Muscovites from diseases of nervous system for the period 1999-2021 was analyzed on the basis of Rosstat data. The analysis of contribution of the death causes from the heading "Other disorders of the nervous system" was carried out on the basis of Moscow RFU-EMIAS database on people who died from nervous diseases in period 2019-2021. Proportion of individual diseases among all causes of death, frequency of indicating diseases of the nervous system in the second part of medical certificate for death from COVID-19 and the average age of death from some diseases were analyzed. Comparison of the proportions of individual death causes in different years was carried out using four-field tables with Chi-square test, the significance level of the test was p to mortality from nervous diseases. These losses are largely due to degenerative diseases of the nervous system with code G31 and lesions of the central nervous system with code G96.8, i.e. associated with SARS-COV-2 infection. Conclusion. Over two years of the pandemic, the structure of death causes from diseases of the nervous system has changed significantly for both male and female mortality. There has been a significant increase in mortality from causes of "Other disorders of the nervous system" block.