Introduction. The indicator of life expectancy of the population is the main indicator for assessing the quality of life of the population, is among the most important demographic indicators and is an integral measure of mortality losses among the population. To manage the process of increasing the life expectancy of the population, modern methods of studying it and assessing the relationship with mortality are needed. Aim. Presentation of the methodology for calculating the standardized indicator of life expectancy of the population and analysis of this indicator in the Krasnoyarsk Territory. Materials and methods. The research is based on the methodology for calculating and interpreting the indicator of the life expectancy of the population standardized for causes of death. The main essence of the standardization of the indicator of life expectancy is to use in calculating the age structure of the deceased as a whole, but only the structure of those who died from a specific cause. The presentation of the results of the application of this technique in the form of a retrospective observational study was carried out using data from the primary mortality database of the Krasnoyarsk Territory in 2020, as well as data on the age-specific population of the Krasnoyarsk Territory. Results. Significantly lower than the actual values of life expectancy in 2020, the values of the standardized indicator of life expectancy were obtained for external causes (62.82 years) and diseases of the nervous system (64.40 years). The highest values of standardized indicators of life expectancy were obtained for mental disorders and behavioral disorders (73.67 years), diseases of the genitourinary system (73.40 years), diseases of the circulatory system (73.16 years) and COVID-19 (72.31). For most causes of death related to diseases of the circulatory system and neoplasms, standardized indicators are higher than the actual value of life expectancy of the population of the Krasnoyarsk Territory in 2020. Discussion. Analyzing the standardized indicator of life expectancy by the main classes of causes of death, attention is drawn to the fact that among the main causes forming the top five in the Krasnoyarsk Territory in 2020 in terms of the number of deaths in relation to three, the standardized indicator is higher than the value of the actual indicator of life expectancy (diseases of the circulatory system, neoplasms and COVID-19). At the same time, among the causes from which a sufficiently large number of deaths occur, some infectious and parasitic diseases and diseases of the digestive organs can be distinguished. Conclusion. The presented methodology, along with other approaches and indicators, can be one of the elements of the methodology of medical care planning and policy formation in the health system at the national and regional levels.