Background. Currently, in the entire world population, there is both a trend towards an increase in the number of people over 65 years of age, and an increase in the number of patients suffering from type 2 diabetes mellitus. Osteoarthritis is the most common disease of the musculoskeletal system in the elderly and senile. The presence of conditions in patients such as frailty, type 2 diabetes mellitus and osteoarthritis is an important public health problem due to the cost of their treatment and associated complications. Evaluation of the relationship of these three conditions in elderly patients is relevant. Aim. To reveal the relationship between osteoarthritis and frailty in elderly and old women with type 2 diabetes mellitus. Materials and methods. The cross-sectional study included 124 women with type 2 diabetes mellitus, mean age 72.64 ± 1.34 years. Patients were divided into two groups to the criterion of the presence/absence of osteoarthritis. According to the results of the "Age is not a hindrance" questionnaire, patients in each of the 2 groups were divided into 3 subgroups: "robust", "with pre-frailty" and "with frailty". The paper considers various anthropometric, metabolic and functional variables of patients. Results. The prevalence of frailty in the group of patients with type 2 diabetes and osteoarthritis was significantly higher than in patients with type 2 diabetes mellitus without articular pathology. In the group of patients with osteoarthritis, a number of indicators of body composition (fat mass, lean mass, active cell mass) and anthropometric parameters (body weight, hip volume, BMI) changed significantly relative to the group of patients not suffering from osteoarthritis. Patients in the osteoarthritis group achieved significantly worse results in walking speed. The Barthel Index in the second group had a significantly higher value. At the same time, there were no significant differences between such parameters as age, height, waist circumference, shoulder circumference, phase angle, proportion of fat mass, skeletal muscle mass, handgrip strength and the 5-sit-to-stand chair test between the two study groups. Conclusions. Women with osteoarthritis of elderly and old age, with type 2 diabetes, such anthropometric parameters and body composition parameters as: body weight, hip volume, fat mass, lean mass, BMI and active cell mass decrease, and parameters such as the Barthel index and walking speed decrease than in patients without this pathology.